The Mouse TLR6 Antibody (N-term) from MyBioSource.com is a Rabbit Polyclonal antibody to TLR6, and toll like receptor 6. This antibody recognizes Human, and Mouse antigen. The Mouse TLR6 Antibody (N-term) has been validated for the following applications: ELISA, Immunohistochemistry, and Western Blot.
Description
TLR6, a Type I membrane protein that belongs to the Toll-like rceptor family, participates in the innate immune response to Gram-positive bacteria and fungi. It acts via MyD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. The protein recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2. It binds to TLR2 via their respective extracellular domains, and to MyD88 via their respective TIR domains. TLR6 is detected in monocytes, CD11c+ immature dendritic cells, plasmacytoid pre-dendritic cells and dermal microvessel endothelial cells